How CloudFuze Helped Exact Sciences Migrate to Microsoft 365
Exact Sciences, the Madison, Wisconsin, healthcare company behind the Colorectal Cancer Screening Test, migrated its content from Box to Microsoft 365 with CloudFuze as its migration partner.
The migration involved transferring shared team content into SharePoint Online, personal user content into OneDrive, and every user and permission, metadata, and file properties. The move gave Exact Sciences one connected Microsoft 365 space for storage and collaboration.
This customer success story breaks down why the company made the switch, the challenges involved, and how CloudFuze delivered it without disrupting daily operations.
Key takeaways:
About Exact Sciences
Exact Sciences is a leading U.S. cancer screening and diagnostics company. Its flagship test, Colorectal Cancer Screening Test, is used by millions of people. The company is headquartered in Madison and employs 7,200 people or more.
What Was Exact Sciences’ Migration to Microsoft 365?
At its core, this was an enterprise content migration from Box into SharePoint Online and OneDrive. While thousands of employees kept working, the scope covered several priorities, such as:
- Migrating files and folders with their structure intact.
- Mapping every Box user to their Microsoft 365 account.
- Routing shared content to SharePoint Online and personal content to OneDrive.
- Preserving sharing permissions so access stayed exactly where it should be.
Why Did Exact Sciences Plan to Migrate from Box to Microsoft 365?
Exact Sciences was already on Microsoft 365, but its content still lived in Box, which meant employees had to switch between two platforms to find, share, and work on files.
The company set out to bring everything under one roof. The main goals were:
- Consolidation: placing content right next to the Teams, Outlook, and Office tools employees used every day.
- A cleaner structure: Giving shared team content a home in SharePoint Online and personal work files a home in OneDrive.
- Security: Moving data in a way that met the standards of a regulated healthcare company.
- Continuity: Keeping lab research and business teams productive throughout the transition.
Migration Challenges Exact Sciences Faced
Enterprise migrations often become challenging not just because of the transfer process itself but also because of other factors around it, and Exact Sciences had several of these factors to plan for:
1. Choosing the Right Migration Partner
The IT team had to evaluate migration partners on both technical and commercial fit and with thousands of users depending on the outcome a wrong choice would have meant delays and rework.
2. Splitting Box Content Across Two Destinations
Box holds personal and shared content in one system while Microsoft 365 separates them. Every folder had to land in the right destination so teams could find their work on day one.
3. Permission and User Mapping
Each Box user and collaboration permission had to map correctly to Microsoft 365. The more users are involved, the higher the chance that a single mismatch exposes sensitive files or locks people out.
4. Healthcare-Grade Data Security
As a healthcare company, Exact Sciences needed full confidence that its data stayed protected from the moment it left Box until it landed in Microsoft 365.
5. Zero Tolerance for Downtime
Employees could not afford to lose access to the files they relied on daily. The migration had to run in the background without slowing anyone down.
6. Box Content that Microsoft 365 Handles Differently
Box allows long folder paths and special characters that SharePoint Online and OneDrive don’t always support. Box Notes, in-line comments, and embedded links also needed a clear migration plan since Microsoft 365 handles each of them differently.
7. Performance for 200 TB Data Volume
Moving 200 TB of data volume demanded high-performance migration infrastructure that would not cause any downtime or disruption.
How did CloudFuze Handle Exact Sciences’ Migration to Microsoft 365?
CloudFuze ran the project as a managed migration, and the Exact Sciences IT team received expert support at every stage.
| CloudFuze’s Approach | What it Delivered |
|---|---|
| Discovery | An in-depth review of the Box environment and Microsoft 365 goals before planning began. |
| Demos led by migration engineers | A walkthrough of exactly how content, users, and permissions would move, with answers to every edge case. |
| Dedicated migration manager | A single point of contact who hand-held the project from planning through cutover. |
| Smart content routing | Shared bot folders mapped to SharePoint Online and personal folders mapped to OneDrive. |
| User and permission mapping | Every Box user and sharing permission matched to the right Microsoft 365 account. |
| Delta migration | A final sync that captured changes users made during the migration so no work was lost at cutover. |
What Were the Migration Results?
CloudFuze completed the Box to OneDrive and SharePoint Online migration and every item in the agreed scope made it across.
| Results | Details |
|---|---|
| All in-scope content migrated | Box files and folders moved to Microsoft 365 with the entire structure preserved. |
| Shared content in SharePoint Online | Team folders landed in the right SharePoint Online sites. |
| Personal content in OneDrive | Every user found their own files waiting in OneDrive. |
| Users and permissions intact | Box users and sharing permissions carried over to Microsoft 365. |
| Zero downtime | Teams kept working throughout the migration. |
| Secure transfer | Data moved in line with healthcare-grade security expectations. |
Why Do U.S. Enterprises Trust CloudFuze for Microsoft 365 Migrations?
There are no two ways about it: an enterprise migration needs a partner that has done it many times before.
As a US-based cloud migration service provider, CloudFuze supports migrations across 40+ cloud platforms, and has run Microsoft 365 migrations for large enterprises such as Estée Lauder, Warner Bros. Discovery, Boston Medical Center, and REHAU.
Our platform preserves files, folders, permissions, versions, timestamps, embedded links, external shares, shared links, and inline comments, and with SOC 2 Type 2, ISO 27001, and GDPR compliance. It meets the security bar that healthcare, life sciences, and other regulated industries expect.
Plan your Box to Microsoft 365 Migration Today
Is your IT team planning to move from Box to SharePoint Online and OneDrive? CloudFuze can help you scope, plan, and run the migration with zero downtime. Book a free consultation and get a customized migration roadmap for your organization.
Frequently Asked Questions
1. Which companies has CloudFuze helped migrate to Microsoft 365?
CloudFuze has helped enterprises such as Exact Sciences, Estée Lauder, Warner Bros. Discovery, Boston Medical Center, and REHAU migrate to Microsoft 365 securely.
2. Where does Box content go in a Microsoft 365 migration?
Shared team content usually moves to SharePoint Online sites, and personal user content moves to each user’s OneDrive. CloudFuze maps both automatically as part of the migration.
3. Can a Box to Microsoft 365 migration run without downtime?
Yes. With CloudFuze users keep working in Box while content migrates in the background and a final delta migration captures any late incremental changes before cutover.
About the Author: Pankaj Rai
